14 Dec how to use edex
Systemic reactions are uncommon with intracavernous injection of edexÂ®. 18. 10. After intravenous infusion of radiolabeled Î±-cyclodextrin to healthy volunteers, the radiolabeled components were rapidly eliminated within 24-hours, urine accounting for 81% to 83% of radioactivity and feces for 0.1%. Each needle and cartridge should be used only once. The mean duration of erection following edexÂ® was 56.9 minutes compared to 4.0 minutes following placebo. EDEX’s tracks Traficante De Armas by EDEX published on 2020-12-11T11:01:10Z. Men with penile implants, severe penile curvature, or those who have been advised not to engage in sexual activity should not use edexÂ®. In a study with a dose range of 1 to 20 mcg of edexÂ®, the mean dose was 10.7 mcg at the end of the dose titration period. Customizable science fiction terminal emulator. Local Adverse Reactions Reported by â¥1% of Patients All Study Periods, Systemic Adverse Experiences Reported by â¥1% of Patients. I cannot deny that, despite the fantastical nature of the film, it had an impact on my career choice later in life. The patient is instructed to follow the enclosed patient information pamphlet. It runs in full screen with sidebars and bottom panels to monitor system and networks stats. If there is no response to the initial 2.5-mcg dose, the second dose may be increased to 7.5 mcg, followed by increments of 5 to 10 mcg. Note: Always attach the needle to the injection device before inserting the cartridge into the injection device. As an endogenous substance, PGE1 exerts its biological effects either directly or indirectly by regulating and modifying the synthesis and effects of other hormones and mediators. 22. If you experience severe pain, contact the prescribing physician. SOUND. Today, I'm taking a quick look at an Electron-based terminal emulator that was heavily inspired by science fiction movies. While eDEX-UI supports only five terminal windows, that has been more than enough for me. The patient is advised not to exceed the optimum edexÂ® dose which was determined in the doctor's office. 4. Precontracted isolated preparations of the human corpus cavernosum, corpus spongiosum and cavernous artery are relaxed by alprostadil. Penile pain was judged by patients to be mild in intensity for 80% of painful injections, moderate in intensity for 16% of painful injections, and severe in intensity for 4% of painful injections. The average dose of edexÂ® remained essentially unchanged throughout the study duration. EDEX. Approximately 93% of PGE1 found in plasma is protein-bound. Some of these conditions include sickle cell anemia or trait, leukemia, and tumor of the bone marrow (multiple myeloma). The pharmacokinetic profiles of aspirin, warfarin, digoxin, and glyburide were not affected by concomitant administration of alprostadil. A potentially serious adverse reaction with intracavernous therapy is priapism. 1) Intracavernous injections of edexÂ® can lead to increased peripheral blood levels of PGE1 and its metabolites, especially in those patients with significant corpora cavernosa venous leakage. To prevent bruising, apply firm pressure to the injection site for 5 minutes. edexÂ® in the Treatment of Erectile Dysfunction. 19. How to install and use eDEX-UI. 17. edexÂ® is supplied in single-dose, dual-chamber cartridges. Among the 71% (81/114) of patients who entered the placebo-controlled phase, an erection sufficient for sexual intercourse was achieved in 74% (60/81) of patients following edexÂ® injection compared to 7% (6/81) of patients following placebo injection. Apply your code and check whether your discount was reflected and continue your checkout. It may be more likely to break… To prevent bruising, apply firm pressure at the injection site for 5 minutes; continue until bleeding stops. People can find numerous options online to consider and shop at Edex, using online coupon codes and discounts. Attach new needle before each dose. @fir0j @rinku98 3 things can cause eDEX to display the network as "offline" when it is not:. You can use eDex to manage and quickly search lists of patients (active, inactive, or archived), employers, insurance carriers, labs, non-patients, providers, staff, referrals, and any other contact you may want to remember. Safely discard the supplies (see the âDiscard Injection Suppliesâ section of these instructions). The edexÂ® cartridges are supplied in the following packages: Store at 25Â°C (77Â°F); excursions permitted between 15Â°C - 30Â°C (59Â°F - 86Â°F). If there is a response, then there should be at least a 1-day interval before the next dose is given. Running eDEX-UI on Linux without installation. Alprostadil also attenuates presynaptic noradrenaline release in the corpus cavernosum which is essential for the maintenance of a flaccid and non-erect penis. Injections should be administered at least 24 hours apart. Doses greater than 40 mcg have not been studied. Choose an injection site mid-shaft on one side of the penis. Yes you can boot into a TTY by disabling GDM or whatever display manager you're using. After the boot, eDEX-UI shows system information, a file browser, a keyboard (for tablets), and the main terminal tab. The frequency of penile pain reports decreased over time; 41% of the patients experienced pain during the first 2 months and 3% of the patients experienced pain during months 21-24. However, they need to be marked as executable before they can be run. Division also reserves the right to audit the use made of any EDEX information obtained by or for the Subscriber and/or its clients. The email address you used to register with edX. On a desktop, eDEX-UI allows all of that and lets me look cool in front of my co-workers. Dr. Y. Urologist. In clinical studies, geriatric patients required, on average, higher minimally effective doses and had a higher rate of lack of effect (optimum dose not determined). In the event of an overdose, supportive therapy according to the presence of other symptoms is recommended. Need help signing in? Alprostadil is used only when needed. You should not stop taking any prescription medications, unless told to do so by your doctor. of the vial. The reconstituted drug solution should be used immediately after reconstitution. This allows you to set the shell command for the terminals, change the theme, and modify several other settings for the user interface. Check to see if the seal on the base of the needle is intact. Seventy-six percent (87/114) of patients had an erection with a positive penile Buckling Test. To use the eDEX-UI AppImage on Linux, make it executable (right click it, select Properties, then enable executing the file as program) and then simply double click the.AppImage file to run it. Edex is used to treat erectile dysfunction (male sexual function problems). It runs in full screen with sidebars and bottom panels to monitor system and networks stats. share. Themes are also stored in the configuration directory and, since they are also JSON files, creating a custom theme is pretty straightforward. This open source project is hosted by GitHub. Pregnancy, Nursing Mothers and Pediatric Use. The injections are painless and very easy to get used to. The dose of edexÂ® that is selected for self-injection treatment should provide the patient with an erection that is satisfactory for sexual intercourse and that is maintained for no longer than 1 hour. After further degradation of PGE1 by beta and omega oxidation, the main metabolites are excreted primarily in urine (88%) and feces (12%) over 72 hours, and total excretion is essentially complete (92%) within 24 hours after administration. Hold the injection device in an upright position with the needle pointing up. Unlike the 15-keto metabolites which are less pharmacologically active than the parent compound, PGE0 is similar in potency to PGE1 in vitro using isolated animal organs. Alprostadil has been shown to bind to specific receptors in human penile tissue. Download the eDEX-UI AppImage and make it executable using your file manager or by entering the following commands in a terminal: chmod +x ./*.AppImage. At launch, eDEX-UI goes through a boot sequence with information about the ElectronJS system it is based on. The drug also widens blood vessels, an action that leads to an increase in blood flow to the penis. You are responsible for ensuring that you have the necessary permission to reuse any work on this site. 5. edexÂ® (alprostadil for injection) is available in single-dose, dual-chamber cartridges intended for use with the reusable edexÂ® injection device. Of the approximately 1,065 patients who entered the in-office dose-titration period in clinical studies, 25% were 65 years or older. Here's the 15th of my picks for 19 new (or new-to-you) open source tools to help you be more productive in 2019. Therefore, caution should be exercised with concomitant administration of heparin and edexÂ®. Download: eDEX-UI Terminal Emulator. If the duration of erection is longer than 1 hour, the dose of edexÂ® should be reduced. One thing to be aware of is that the keys light up on the keyboard while you type, so if you're using eDEX-UI on a tablet, the keyboard could present a security risk in environments where people can see the screen. Access 2000 free online courses from 140 leading institutions worldwide. The dose may be increased by 1.25 mcg to a dose of 2.5 mcg, followed by an increment of 2.5 mcg to a dose of 5 mcg, and then in 5-mcg increments until the dose that produces an erection suitable for intercourse and not exceeding a duration of 1 hour is reached. The patient may expect an erection to occur within 5 to 20 minutes. Safely discard the supplies (see the âDiscard Injection Suppliesâ section of these instructions). Erections that last more than 6 hours can cause serious damage to the penile tissue and may result in permanent impotence. It is better to use a theme without the keyboard on those devices, although it does look pretty cool when you are typing. In connection to using Edex. Mix edexÂ® just prior to injection. The reconstituted solution may initially appear cloudy due to small air bubbles. How to use Edex Kit. edexÂ® Cartridge 6 Pack contains enough supplies for six injections. We found that it hogged a fair amount of CPU and memory, hogging all 4MB of our virtual machine, and made it run very slowly. 13. If you need further assistance you may submit a request to our support team on the article or search pages. Alprostadil alfadex is a white, odorless, hygroscopic powder. 2020-11-20 Set Appimage compression rate to normal Appimage construction used to compress files aggressively. Study 1: One hundred fourteen men with a mean age of 53 years (range 22 to 65 years) were enrolled in the first phase. The first injections of edexÂ® must be done at the physician's office by medically trained personnel. Sharing in spanish in my blog:https://victorhckinthefreeworld.com/2019/01/29/edex-ui-la-interfaz-para-... For more discussion on open source and the role of the CIO in the enterprise, join us at The EnterprisersProject.com. There is also a virtual keyboard for touch devices. This is the eDEX-UI using the “blade” theme, stop Run in its terminal: As you can see from the screenshot, eDEX-UI uses a lot of CPU (htop shows the CPU usage of each core, although this is not the total CPU usage), but its purpose is not to do actual work or monitoring system. Email. Alprostadil showed no evidence of mutagenicity in three in vitro assays including the AMES bacterial reverse mutation assay, a forward gene mutation assay in Chinese hamster lung (V79) cells, and a chromosome aberration assay in human peripheral lymphocytes. 3 months), is strongly recommended to identify any penile changes. In patients infected with blood-borne diseases, this could increase the risk of transmission of blood-borne diseases between partners. No unchanged PGE1 has been found in the urine and there is no evidence of tissue retention of PGE1 and its metabolites. Do not discard this swab; you will need to use it later. The needle must be properly discarded after use; it must not be reused or shared with other persons. Alprostadil is an endogenous substance known as prostaglandin E1 (PGE1). The physician should make a careful assessment of the patient's skills and competence with the self-injection procedure. There is also a virtual keyboard for touch devices. The other four tabs (labeled EMPTY) don't have anything loaded and will start a shell when you click on one. Use of intracavernous edexÂ® offers no protection from the transmission of sexually transmitted or blood-borne diseases. The human dose of edexÂ® is <1 mcg/kg (MRHD is 40 mcg and the calculation assumes a 60-kg subject). Patients should be aware of possible side effects of therapy with edexÂ®; the most frequently occurring is penile pain during and/or after injection, usually mild to moderate in severity. Visible veins should be avoided. In the majority of cases, spontaneous detumescence occurred. If your partner experiences insufficient vaginal lubrication or painful vaginal sensations during intercourse, the use of a lubricant may be helpful. This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. The edexÂ® injection device is used to reconstitute the sterile powder in one chamber with the sterile 0.9% sodium chloride in the other chamber. Join today. The effects of alprostadil on an unborn baby at conception or during pregnancy are unknown. Wipe the injection site with a new alcohol swab. After reconstitution, the edex ® injection device is used to administer the intracavernous injection of alprostadil. The patient is strongly encouraged to go to the nearest emergency room if his personal physician is not available. edexÂ® is injected into a specific area of the penis (see injection directions below) and should produce an erection in 5 to 20 minutes. In addition, there are no data on the efficacy and safety of these combinations. The physician should instruct the patient to discard any needles which become bent during the self-injection procedure as these needles may break. It doesn't have to be that way. The site of injection is usually along the lateral aspect of the proximal third of the penis. I draw out 10mcg from a separate syringe, Idea is to have remaining 10mcg. This run features lecture videos, lecture exercises, and problem sets using Python 3.5. The pulmonary extraction of alprostadil following intravascular administration was reduced by 15% (66 Â± 3.6% vs 78 Â± 2.3%) in patients with acute respiratory distress syndrome (ARDS) compared with a group of patients with normal respiratory function who were undergoing cardiopulmonary bypass surgery. Stream Tracks and Playlists from EDEX on your desktop or mobile device. A new graphical settings editor in a draggable modal window allows you to tweak edex without opening the notepad. The above value exceeded cardiac output indicating extensive and rapid elimination of PGE1 in the lungs and/or blood. Sign in here using your email address and password, or use one of the providers listed below. Tom-slick. A Linux Sysadmin and Open Source advocate, Kevin has over 25 years in the IT industry, with over 15 years in Open Source. Works perfectly. PGE1 is metabolized in the corpus cavernosum after intracavernous administration. SoundCloud. A normal cake may appear cracked or crumbled. The pharmacokinetic and pharmacodynamic interaction between alprostadil intravenous infusion, 90 mcg over 3 hours, and heparin (5,000 IU) was evaluated in 12 healthy volunteers. EDEX- alprostadilÂ injection, powder, lyophilized, for solutionÂ Endo Pharmaceuticals, Inc. Sterile Powder and Diluent(sterile 0.9% sodium chloride) in Cartridges. If there is a partial response, the dose may be increased by 2.5 mcg to a dose of 5 mcg and then in increments of 5 to 10 mcg, depending upon erectile response, until the dose that produces an erection suitable for intercourse and not exceeding a duration of 1 hour is reached. edexÂ® (alprostadil for injection) is a sterile, pyrogen-free powder containing alprostadil in an alfadex (Î±-cyclodextrin) inclusion complex. Tried 15 and that worked fine for a while before becoming painful particularly during penetration. If there is a response, then there should be at least a 1-day interval before the next dose is given. Download eDEX-UI - View various information about the system resource usage and network stats in a futuristic framework using this emulator application Sandboxing eDEX-UI. The lowest effective dose should be used at home. and use the edex terminal as default. The volume of distribution for PGE1 was not estimated. Alprostadil did not cause any adverse effects on fertility or general reproductive performance when administered intraperitoneally to male or female rats at dose levels from 2 to 200 mcg/kg/day. Do not touch the exposed needle (Figure B). An erection should occur within 5 to 20 minutes and last up to 60 minutes. In placebo-controlled studies, penile pain was reported by 31% of patients after edexÂ® and by 9% of patients after placebo injection. Increased peripheral blood levels of PGE1 and its metabolites may lead to hypotension and/or dizziness. The default terminal type is xterm-color, meaning it has full-color support. in men who have conditions that predispose them to priapism, such as sickle cell anemia or sickle cell trait, multiple myeloma, or leukemia, for the treatment of erectile dysfunctionÂ in men with fibrotic conditions of the penis, such as cavernosal fibrosis or Peyronieâs disease. (Also, see Drug-Drug Interactions in CLINICAL PHARMACOLOGY, Pharmacokinetics.). Antigen tests … If the dosage prescribed is less than 1 mL of edexÂ® solution, excess solution will be expelled through the needle as the plunger is pushed and the upper rim of the top stopper reaches the correct volume mark for the prescribed dose. Tell your doctor if you have a condition or are taking a medicine that interferes with blood clotting. If the cartridge is damaged, the cake may shrink in size. The terminal half-lives of PGE1, PGE0, and 15-keto-PGE0 and plasma albumin levels were similar in patients compared to healthy volunteers. “I have been using Edex for 20 months after a Da Vinci prostatectomy. One thing to be aware of is that the keys light up on the keyboard while you type, so if you're using eDEX-UI on a tablet, the keyboard could present a security risk in environments where people can see the screen. Gently move the injection device in a back and forth motion until the drug has dissolved and the solution is clear. The lowest possible effective dose should always be used. In placebo-controlled studies, 3% of patients treated with edexÂ® and <1% of patients treated with placebo reported prolonged erections greater than four hours. After intracavernous administration in monkeys, radiolabeled Î±-cyclodextrin was rapidly distributed from the injection site with less than 0.1% of the dose remaining in the penis 1 hour after administration. edex ® is injected into a specific area of the penis. Please read this information carefully before you prepare the edexÂ® solution. If you do not yet have an account, use the button below to register. Ask your doctor or pharmacist where you can obtain these special containers. Accordingly, the patient should be instructed to contact the physician's office immediately or, if unavailable, to seek immediate medical assistance if an erection persists for longer than 6 hours. At that time, the efficacy and safety of the therapy should be assessed, and the dose of edexÂ® should be adjusted, if needed. Be sure to use only the dose prescribed by your doctor. PGE1 entering the systemic circulation is rapidly and extensively metabolized in the lungs with a first-pass pulmonary elimination of 60 to 90% of PGE1. Your dose has been customized for your individual needs. Alprostadil induces erection by relaxation of trabecular smooth muscle and by dilation of cavernous arteries. Overall differences in safety were not observed between these geriatric patients and younger patients. eDEX-UI is essentially a terminal emulator. Self-injection therapy by the patient can be started only after the patient is properly instructed and well trained in the self-injection technique. For more information, call Endo Pharmaceuticals Inc.Â at 1-800-462-3636. eDex is an electronic contact manager and directory available in Dentrix G6. The following systemic adverse experiences were reported in controlled and uncontrolled studies in â¥1% of patients treated for up to 24 months with edexÂ®. 4 Replies. Erectile dysfunction is often due to more than one of these causes. Thereafter, patients continued to perform self-injections of open-label edexÂ® for six or 12 months, and the occurrence of an erection sufficient for sexual intercourse was documented following each injection. Pick up the cartridge and wipe the tip of the cartridge with an alcohol swab. Wash your hands thoroughly with soap and water and dry them with a clean towel. After reconstitution, the active ingredient, alprostadil, immediately dissociates from the Î±-cyclodextrin inclusion complex. Do not touch the exposed needle or allow the needle to touch anything. eDEX-UI It is an application similar to the Sci-Fi computer interface, which creates the illusion of a desktop environment without Windows. A patient information pamphlet is included in each package of edexÂ® cartridges. Treatment for erectile dysfunction includes penile injections, medical devices that produce an erection, surgical procedures (e.g. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. Carcinogenesis, Mutagenesis, Impairment of Fertility. edexÂ® should be used immediately after reconstitution. Therefore, the use of such combinations is not recommended. Discard your needle in a special container for disposal of sharp medical supplies. Attach the needle to the tip of the edexÂ® injection device by turning clockwise until tight (Figure C). The patient must visit the physician's office for regular checkups for assessment of the therapeutic benefit and safety of treatment with edexÂ®. Changing directories in the file browser will change directories in the active terminal and vice-versa. Additionally, change the font, text size, enable a window mode, hide the keyboard from the screen, etc. 20,438 satisfied customers. In clinical trials, concomitant use of agents such as antihypertensive drugs, diuretics, antidiabetic agents (including insulin), or nonsteroidal anti-inflammatory drugs had no apparent effect on the efficacy or safety of edexÂ®. In a study in symptomatic subjects with end-stage renal disease undergoing hemodialysis and age/weight/sex-matched healthy volunteers, 120 mcg of alprostadil was administered by intravenous infusion over 2 hours. To occur within 5 to 10 second interval prescription medicines, the cake shrink. A bunch of extra sounds & loops to really get in the majority of cases, spontaneous detumescence.. Edex® at home and tumor of the cartridge is damaged, the cake may shrink in.... An Electron-based terminal emulator that was heavily inspired by DEX-UI Projects ( not updated since early 2015 ) TRON. Surgical procedures ( e.g and younger patients AIDS ) 2 ) regular follow-up the! Is included in each package of edexÂ® remained essentially unchanged throughout the study duration that! Report to the physician 's office should not allow anyone else to use only the dose of must... 2 ) regular follow-up of patients after edexÂ® and by dilation of cavernous.! This: Facebook Twitter Diaspora Reddit Telegram WhatsApp 2 Pack contains enough supplies for two injections proper patient handling injection... Mandates that all rat negative samples from symptomatic people must be retested using PCR, it is that... Fullscreen, cross-platform terminal emulator app for Ubuntu has many great features cartridge will need to compile,! Fully trained on the pharmacokinetics of alprostadil, using online coupon codes and discounts of is. If I remove the welcome screen and sound effects at startup and when typing and receiving output ( you run! 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Hide the keyboard on those devices, although it does look pretty cool when you click a! Swab before injection muscle and by dilation of cavernous arteries and discard needles and cartridges or! Rat negative samples from symptomatic people must be weighed against the good it will do hypotension as... Last up to 60 minutes display the network as `` offline '' when it is not treated immediately penile! Then the next dose is given as an SRE at, 6 open tools... Range 1 to 40 mcg to discard any needles which become bent during the dose-titration phase, self-injected. A response, then there should be used by women or children injection technique before using, this... Should follow the instructions for administration which are described below individual dose titration are essential for the discrepancies... Attenuates presynaptic noradrenaline release in the proper disposal procedures used edex for over 3 hours ) was investigated parenteral products... 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Your system the observed discrepancies between renally impaired subjects and healthy volunteers in cases. Using Python 3.5 ; temperature variations between 15Â°C - 30Â°C ( 59Â°F - 86Â°F ) allowed!